Watched my coworker move her cursor to the right edge of her right-hand monitor to get it to over to the left side of her left-hand monitor. When I offered to show her how to adjust her display settings, she said she was used to it and didn’t want to change it. I don’t think I can walk by her desk while she’s working ever again.
What have you got?
To be fair, I’ll use the more convenient shortcuts (cut/copy/paste, select all, save) that are genuinely easier to do with one hand. But Alt+F4? It either requires two hands or else your hand needs to qualify for Cirque de Soleil to hit it properly. Some of the “standard” keybinds are often more trouble than moving the pointer.
cmd+Q on macOS is great.